The research group BIO-212: Biochemical and Genetic Regulation of Metabolism studies from the molecular point of view the mechanisms of regulation of gene expression that affect metabolism in pathophysiological situations in humans and animal experimental models.

This includes the identification, study of the expression and determination of the molecular mechanisms of regulation of metabolic pathways, transduction of intracellular signals and mechanisms of action of key regulatory enzymes in metabolism. These studies are applied to the identification of molecular targets that may be key for the development of targeted therapeutic agents, the regulation of metabolism by drugs and nutrients in the diet, and for the design of diagnostic systems for these pathophysiological processes.

Thus, the research group has developed tools in recent years to study these processes at a molecular level in cell cultures and animal models, including techniques over-expression of recombinant proteins, gene silencing, and design of molecular sensors based on the use and modification of green fluorescent proteins. These studies are applied to the study of pathophysiological processes such as cancer, diabetes, proliferation and differentiation of muscle cells, sarcopenia, obesity or defects in membrane transporter proteins.