SVN-438

FQM-283: Transition metal complexes of bioinorganic and therapeutic interest

The FQM283 research group originated in 1988 when the Junta de Andalucía, in its research and development plan (PAIDI) created the group structure that has survived to the present day. At the beginning, the coordination was in charge of Prof. Salvador González García. After his death in February 1997, Prof. Juan Niclós Gutiérrez took over the coordination. With the change of direction came also, some years later, the change of name from "Design and study of palladium antitumour compounds" (codes 3081 and later CTS157) to "Transition metal ion complexes, bioinorganic and therapeutic interest" (FQM283).


The group is currently headed by Prof. Antonio Matilla Hernández, who coordinates the members of the group, 8 PhDs and 2 graduates.


The FQM283 group specialises mainly in the preparation and characterisation of coordination compounds (including mixed compounds) with transition metal ions and ligands derived from amino acids, nitrogenous bases, peptides and nucleobases. In addition, some of its members have experience in using and working with radiopharmaceuticals. In this regard, it should be noted that two of its members (A. Matilla Hernández and Francisco J. Pérez Jiménez) are director and technician, respectively, of the Radiopharmacy unit, located in the Faculty of Pharmacy of the UGR. The new additions to the group have made it possible to include a new line of research on the preparation and characterisation of nanomaterials for environmental and biomedical applications, for which Dr. Manuel Sánchez Polo is responsible.


The productivity of the group is reflected in 467 contributions to conferences, 359 publications in journals, 67 theses, dissertations, DEA and 50 R+D+i projects and other grants.


The main lines of research are the following:


- Applications of radiopharmaceutical techniques in the study of biological systems.


- Study of the coordinating preferences of amino acid derivatives and nitrogenous bases in M(II) complexes (M=Cu(II), Co(II), Ni(II)...).


- Preparation and study of ternary complexes of oligopeptides and nucleobases with transition metals.


- Formation of multicomponent pharmaceutical solids to improve the physicochemical properties of drugs.


- Synthesis and characterisation of nanomaterials for environmental and biomedical applications.



Group website

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