Development, stability study, delivery and permeation of different formulations that although of topical application, could have a particularly topical or systemic action. In this regard, the mathematical models can predict both the way in which the active principles are released from the formulation and the optimal applied quantity to achieve therapeutic levels. Furthermore, and depending on the results obtained, the formulations can be modified using encapsulation in delivery systems such as liposomes or transdermal gels.