Many of the cellular signal transduction pathways are mediated by protein kinases, which regulate many aspects of cellular function. Dysregulation of the expression or function of these enzymes leads to the formation of various tumours, and the design of protein kinase inhibitors has become an important strategy in the development of new therapies in cancer treatment.

Choline kinase has proven to be a key enzyme as a therapeutic target in the design of new molecules with antiproliferative activity. A wealth of information is now available on inhibitors of this enzyme, on the enzymatic process and on the enzyme itself, which has opened the door to the development of new and more potent inhibitors obtained by rational design techniques. 

In this multidisciplinary line of research, the design, synthesis and biological evaluation of new and more potent inhibitors of this enzyme, which should also have a high capacity as antiproliferative agents and could be useful in the development of new anti-tumour drugs, is being carried out. Many of the cellular signal transduction pathways are mediated by protein kinases, which regulate many aspects of cellular function. Dysregulation of the expression or function of these enzymes leads to the formation of various tumours, and the design of protein kinase inhibitors has become an important strategy in the development of new therapies in cancer treatment.
Choline kinase has proven to be a key enzyme as a therapeutic target in the design of new molecules with antiproliferative activity. A wealth of information is now available on inhibitors of this enzyme, on the enzymatic process and on the enzyme itself, which has opened the door to the development of new and more potent inhibitors obtained by rational design techniques. 

In this multidisciplinary line of research, the design, synthesis and biological evaluation of new and more potent inhibitors of this enzyme, which should also have a high capacity as antiproliferative agents and could be used in the development of new anti-tumour drugs, is being carried out.