The group was formed in 1987 and was added, as an independent group, to the list of groups of the Andalusian Regional Government in 1994, under the study group heading of Physiopathology of Arterial Hypertension with reference number CTS-251.

The group is located in three centres: The Department of Physiology, Granada Faculty of Medicine, where the vascular function laboratory is found, the Research Unit of the Virgen de las Nieves Hospital in Granada, where the laboratory for study of renal function is located, and the Department of Health Sciences of the University of Jaen, where long term studies are undertaken.

The research activity of the group is divided into two areas, one related to the study of physiology and physiopathology of the regulation of arterial pressure and hydroelectrolytic homeostasis in experimental arterial hypertension and in anomalies of thyroid function. Furthermore, the role of oxidative stress has been studied in the pathogenesis of hypertension and the effect of antioxidants on its development. Recently, the role of urinary aminopeptidases as markers of renal lesion in various renal pathologies in animals and humans has been studied. Furthermore, the role of thyroid hormones is being studied in angiogenesis, development of tumours and healing of injuries.

The main lines of research are as follows:

- Urinary aminopeptidases as markers of renal injury and fibrosis.

- Role of oxidative stress, endothelial actors and vasoactive agents in arterial hypertension.

- Role of thyroid hormones in hypertension, angiogenesis, solid tumour development and wound healing of injuries

- Role of thyroid hormones in the kloto-FGF23-Vit D axis

- Urinary exosomes in the diagnosis, prognosis and therapy of renal dysfunction.