The aim of the group is to develop new biotechnological tools to be applied to biological systems in order to interrogate in-vitro and in-vivo models.

The main research lines are:

• Enzyme-free nucleic acid detection and identification.
• Encoded small-molecules and sugars libraries using SMART-tags.
• Microarrays y lab-on-a-chip as “high-throughput screening” platforms for enzymatic and cell-based assays.
• Cellular delivery of small-molecules using peptides and nanoparticles as selective delivery agents.

Members of the group have  developed DNA microarray technologies which have allowed to interface DNA arrays with combinatorial libraries. PNA-encoded libraries with 10,000 peptides were developed and successful used to study kinases and proteases for the very first time. Currently, this technology is being used to develop "The Oncokinase Chip" within the Dutch CTMM BioCHIP project. This technology has also allowed to find new peptide substrates for the protease chymopapain.

The groups has also been involved in the development of cell-based polymer microarrays, finding materials which increase transfection efficiency, keep bone-marrow dendritic cells in their immature state and allow immobilisation of lymphocytes amongst others.