SVN-438
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Interactions between the bacteria Yersinia enterocolitica and the immune system

Yersinia enterocolitica is a bacterium capable of colonising the intestine over a long period without causing any significant symptomatology. This bacterium is capable of interacting with the immune system, potentiating, in a non specific way, cell immunity responses. A consequence of this activity is the capability to induce in the mouse resistance to lethal doses of the intracellular pathogen Listeria monocytogenes. The study of the non specific interactions between Y. enterocolitica and immunity is very interesting because it allows the mechanisms responsible for immunopathological manifestations (such as autoimmune thyroiditis) that are associated with human yersinosis such as aseptic sequelae to be known. Furthermore, the characterisation of bioactive fractions in this bacterium is the first step to their possible application as immunodrugs. 

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